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Gibco™
CTS™ TrueCut™ Cas9 Protein
Gibco CTS TrueCut Cas9 Protein is our highest performing CRISPR-Cas9 protein, engineered to deliver maximum ribonucleoprotein (RNP)-editing efficiency. This protein了解更多信息
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| 货号 | 数量 |
|---|---|
| A45220 | 2.5 mg |
| A45221 | 5 mg |
货号 A45220
价格（CNY)
78,695.00
Each
数量:
2.5 mg
价格（CNY)
78,695.00
Each
Gibco CTS TrueCut Cas9 Protein is our highest performing CRISPR-Cas9 protein, engineered to deliver maximum ribonucleoprotein (RNP)-editing efficiency. This protein is manufactured in compliance with standards for Ancillary Materials for Cell, Gene and Tissue-Based Products and is subjected to stringent quality specifications. It is provided in a high-concentration and large-scale format for process development and clinical research applications.
Features of CTS TrueCut Cas9 Protein include:
• Consistent high editing efficiency—superior CRISPR-Cas9 editing efficiency in all tested cell lines including primary immune cells (>90% editing in primary T cells)
• Higher stringency manufacturing—manufactured to meet the standards for Ancillary Materials for Cell, Gene, and Tissue-Based Products including USP <1043>, Ph.Eur. 5.2.12, and ISO 20399, following the principles of 21 CFR Part 820 in a FDA-registered manufacturing site
• Aseptic manufacturing—entire process completed using single-use technology
• Extensive safety testing—includes sterility, endotoxin, mycoplasma, residual nucleic acids, and proteins
• Sterile filling—finished product is vialed in a Class A/B (Class 100 and ISO 5 equivalents) cleanroom
• Traceability documentation—COA, COO, Drug Master Files, and Regulatory Support Files are available
CTS TrueCut Cas9 Protein is a Streptococcus pyogenes Cas9 (wt) protein, produced by recombinant DNA technology in E. coli for genome editing with CRISPR technology. Cas9 protein forms a very stable RNP complex with the guide RNA (gRNA) component of the CRISPR/Cas9 system. Incorporation of NLS aids delivery to the nucleus, increasing the editing efficiency and on-target cleavage.
If you would like to evaluate our TrueCut Cas9 protein or conduct small-scale research experiments, we recommend using our TrueCut Cas9 Protein v2.
Features of CTS TrueCut Cas9 Protein include:
• Consistent high editing efficiency—superior CRISPR-Cas9 editing efficiency in all tested cell lines including primary immune cells (>90% editing in primary T cells)
• Higher stringency manufacturing—manufactured to meet the standards for Ancillary Materials for Cell, Gene, and Tissue-Based Products including USP <1043>, Ph.Eur. 5.2.12, and ISO 20399, following the principles of 21 CFR Part 820 in a FDA-registered manufacturing site
• Aseptic manufacturing—entire process completed using single-use technology
• Extensive safety testing—includes sterility, endotoxin, mycoplasma, residual nucleic acids, and proteins
• Sterile filling—finished product is vialed in a Class A/B (Class 100 and ISO 5 equivalents) cleanroom
• Traceability documentation—COA, COO, Drug Master Files, and Regulatory Support Files are available
CTS TrueCut Cas9 Protein is a Streptococcus pyogenes Cas9 (wt) protein, produced by recombinant DNA technology in E. coli for genome editing with CRISPR technology. Cas9 protein forms a very stable RNP complex with the guide RNA (gRNA) component of the CRISPR/Cas9 system. Incorporation of NLS aids delivery to the nucleus, increasing the editing efficiency and on-target cleavage.
If you would like to evaluate our TrueCut Cas9 protein or conduct small-scale research experiments, we recommend using our TrueCut Cas9 Protein v2.
For Research Use or Non-Commercial Manufacturing of Cell-Based Products for Clinical Research. Caution: Not intended for direct administration into humans or animals.
规格
最大浓度10 mg/mL
表达系统E. coli
生产质量ISO13485
产品类型Cas9 Protein
数量2.5 mg
研究类别Genome Editing
有效期36 months from date of manufacture
运输条件Dry Ice
无菌Sterile-filtered
适用于（应用）Cell and Gene Therapy Research, Development, and Manufacturing
形式Liquid
Unit SizeEach
内容与储存
Store at –20°C.